Cell子刊:中科院動物所王宇研究組發表Hedgehog通路從基礎研究到臨床轉化綜述
2017年3月10日,國際著名學術雜誌《Cell》子刊《Cell Chemical Biology》雜誌線上發表了中國科學院動物研究所王宇研究組撰寫了題為Hedgehog Signaling: From Basic Biology to Cancer Therapy 的綜述文章。王宇組研究生吳付佳為第一作者,通訊作者為王宇研究員。
Hedgehog信號通路是某些成體幹細胞和腫瘤幹細胞的核心信號通路之一,
小分子調控機制的研究,尤其是面向Hedgehog通路這類重要靶點的研究,往往發展成為通向臨床藥物的鑰匙,
Hedgehog信號通路內源小分子調控機制的假說模型
原文連結:
原文摘要:
The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in embryonic patterning and development. Since its discovery, it has become increasingly clear that the HH pathway also plays important roles in a multitude of cancers. Therefore, HH signaling has emerged as a therapeutic target of interest for cancer therapy. In this review, we provide a brief overview of HH signaling and the key molecular players involved and offer an up-to-date summary of our current knowledge of endogenous and exogenous small molecules that modulate HH signaling. We discuss experiences and lessons learned from the decades-long efforts toward the development of cancer therapies targeting the HH pathway. Challenges to develop next-generation cancer therapies are highlighted.